Non sedating anti allergic


So that’s where they’re best positioned to serve out their principal role and defense. And then the genitourinary tract is another environmental interface.So all sorts of irritation and pain in the urinary tract, sometimes the genital tract, and there can be other inflammatory type problems in that area as well. And there also may or may not be assorted abnormalities of growth and development in, well, potentially any tissue really.



And you know, Michael, that when the immune system isn’t working right, there’s a wide range of possible consequences, including increased susceptibility to infection and increased difficulty with healing or recovering from infections and wounds and increased risk for malignancies and even increased risk for autoimmunity of potentially any sort. So, Lawrence, thank you so much for being on the show. And the more I began looking for it in my other mysteriously ill patients, the more I began finding it. And then, there’s the much larger bulk of the iceberg below the waterline. And I’m very excited to discuss mast cell activation disorder and/or histamine intolerance and kind of pick into some of these specifics and where to draw the line between the two and how we can diagnose, how we can treat, and really delve into this gentleman’s brain, who has quite a bit of expertise in that area. And through all I learned in diagnosing her, I began to realize this might be a whole lot more common than anybody might’ve suspected previously. And can you define for us what mast cell activation disorder is? The term mast cell activation disorder, or MCAD, actually is the new, call it an umbrella term, the term for describing the whole realm of diseases of the mast cell. There’s the part of the iceberg you can fairly easily see above the waterline, a waterline of relatively easy clinical recognizability, if you will.There’s the cardiovascular system with all sorts of autonomic issues, a lot of variability in pulse and blood pressure, palpitations, tachycardia. You can get issues with the hair and the teeth and the nails. There’s the GI tract; all sorts of issues in the GI tract with reflux and nausea, sometimes vomiting and diarrhea or constipation or, even more commonly, sort of an alternating back and forth between diarrhea and constipation, which is just one example of the many opposites you can see with this disease.

You mentioned in the musculoskeletal system a lot of pain, diffusely migratory pain. Even in the same patient, just from one point in time to the next, the disease can manifest opposite symptoms, which can really frustrate not only the patients but also the doctors trying to diagnose this.

So mast cell activation disorder or disease, MCAD, the whole iceberg, features just different patterns of mast cell activation, inappropriate, obviously, mast cell activation.